Selank
Synthetic heptapeptide (tuftsin analogue)
Also known as TP-7, Thr-Lys-Pro-Arg-Pro-Gly-Pro
A synthetic analogue of the immunomodulatory tetrapeptide tuftsin, extended with a Pro-Gly-Pro tail for stability. Developed in Russia and studied in anxiety and cognition models.
Technical information
Values are shown with their status. “Verified” means the value has been checked against a primary database such as PubChem.
- Classification
- Synthetic heptapeptide (tuftsin analogue)
- CAS number
- 129954-34-3 Pending
- Molecular formula
- C33H57N11O9 Pending
- Molecular weight
- 751.9 g/mol Pending
- Sequence / structure
- Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) Pending
Some values are still being checked and should be treated as provisional until marked verified.
How this compound is tested
Heptapeptide: LC-MS identity and HPLC purity.
Research background
Selank was developed at the Institute of Molecular Genetics (Russian Academy of Sciences) and is registered as a medicine in Russia for anxiety disorders. Outside Russia it has no regulatory status. The research literature includes rodent behavioural studies and small Russian clinical studies.
Mechanisms investigated in published research
These are the mechanisms examined in the cited literature. Describing them is not a claim that the compound produces any effect in humans.
- Reported modulation of GABAergic and monoaminergic signalling in rodent brain.
- Proposed effects on brain-derived neurotrophic factor (BDNF) expression.
- Immunomodulatory activity inherited from the tuftsin core, examined in cell models.
Summary of evidence
Laboratory and animal findings are kept separate from human clinical evidence.
Preclinical findings
Rodent anxiety and learning models reported anxiolytic-like and pro-cognitive effects in Russian-institute studies.
Human clinical evidence
Small Russian clinical studies supported domestic registration; these have not been replicated in international, peer-reviewed controlled trials. No approval in the UK, EU or US.
Limitations and open questions
- Literature largely Russian-language and institute-authored.
- Study designs often lack blinding or adequate controls by international standards.
Scientific references
Publications cited on this page. Links open the publisher or PubMed record.
No references have been published for this entry yet.
Research use only
Selank is described here for laboratory research. It is not approved for human or veterinary use unless a regulator has said otherwise, and nothing on this page is medical advice or guidance on administration. A disclaimer does not by itself make any activity lawful. Full disclaimer.
Contact options
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