DSIP
Naturally occurring nonapeptide (synthetic form)
Also known as Delta sleep-inducing peptide
A nonapeptide first isolated from rabbit cerebral venous blood in the 1970s on the basis of sleep-inducing activity. Its physiological role remains unresolved.
Technical information
Values are shown with their status. “Verified” means the value has been checked against a primary database such as PubChem.
- Classification
- Naturally occurring nonapeptide (synthetic form)
- CAS number
- 62568-57-4 Pending
- Molecular formula
- C35H48N10O15 Pending
- Molecular weight
- 848.8 g/mol Pending
- Sequence / structure
- Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) Pending
Some values are still being checked and should be treated as provisional until marked verified.
How this compound is tested
Nonapeptide: LC-MS identity and HPLC purity.
Research background
DSIP was characterised by Schoenenberger and Monnier (1977) following experiments in which blood from sleep-stimulated rabbits induced slow-wave sleep in recipients. Despite decades of study, no receptor has been identified and the peptide's endogenous function is still debated. It has been studied in sleep, stress and pain models.
Mechanisms investigated in published research
These are the mechanisms examined in the cited literature. Describing them is not a claim that the compound produces any effect in humans.
- No receptor identified; proposed interactions with GABAergic and opioid systems are hypothetical.
- Reported effects on stress-hormone secretion in animal models.
Summary of evidence
Laboratory and animal findings are kept separate from human clinical evidence.
Preclinical findings
1 citedEarly rabbit and rodent sleep-EEG studies; later rodent studies in stress and withdrawal models with inconsistent findings.
Human clinical evidence
Small human studies in the 1980s–90s examined sleep and pain endpoints with mixed or null results. No approved medicine.
Limitations and open questions
- Fundamental uncertainty about physiological role and mechanism.
- Historical studies with small samples and inconsistent methods.
Scientific references
Publications cited on this page. Links open the publisher or PubMed record.
[1]Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proceedings of the National Academy of Sciences (1977).
Preclinical Citation pendingOriginal isolation and characterisation (rabbit).
Research use only
DSIP is described here for laboratory research. It is not approved for human or veterinary use unless a regulator has said otherwise, and nothing on this page is medical advice or guidance on administration. A disclaimer does not by itself make any activity lawful. Full disclaimer.
Contact options
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